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KMID : 0939920090410010029
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대한암학회지
2009 Volume.41 No. 1 p.29 ~ p.35
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Osteopontin, CD44, and NF?BExpression in GastricAdenocarcinoma
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Kim Jung-Yeon
Bae Byung-Noe
Kim Kyoung-Soo
Shin Eun-Ah
Park Kyeong-Mee
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Abstract
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Purpose:Osteopontin (OPN) binds to CD44 and nuclear factor-?B (NF?B) and OPN mediatestumorigenesis, invasion and metastasis, but the interrelationships between OPN, CD44and NF?B are not fully understood, and especially in gastric carcinogenesis. We examinedthe expressions of OPN, CD44, and NF?B in untreated gastric adenocarcinomas.
Materials and Methods:The materials from 211 cases of gastric adenocarcinoma were immunostained for OPN,CD44 and NF?B by using a tissue microarray. The OPN mRNA expression was measuredin 10 cases by performing real-time RT-PCR.
Results:The expression of OPN, CD44 and NF?B was noted in 61.7%, 11.4% and 26.6% of theadenocarcinoma tissues, respectively. No significant correlation was detected among theexpressions of these proteins. The OPN protein expression was negatively correlated withangioinvasion (p<0.05) and patient survival (p<0.05), whereas the CD44 and NF?B proteinexpressions were not correlated with any of the clinicopathological factors we examined.The depth of invasion, lymph node status and perineural invasions were prognostic factorsbased on the Cox analysis. The OPN mRNA expression showed no significant differencebetween the adenocarcinoma and the paired normal mucosa on real-time RT-PCR.
Conclusion:OPN may have a currently undetermined role in gastric carcinogenesis, and CD44 and NF?B may have minor roles in gastric adenocarcinoma
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KEYWORD
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Stomach, Adenocarcinoma, Osteopontin, CD44, NF?B
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